Article – MegaBulb DNA: A Non-Viral ssDNA Breakthrough Revolutionising Gene Editing
Touchlight is at the forefront of innovation in gene editing technology with our groundbreaking MegaBulb DNA (mbDNA). This novel, circular, single-stranded DNA template is poised to transform the landscape of gene therapy and CRISPR applications.
In this article, Elena Stoyanova, Ph.D., Senior Scientist, and Tom Adie, Ph.D., Associate Director of Research, explore how mbDNA is overcoming limitations of traditional DNA templates and viral vectors, offering a high-purity, synthetic alternative for precise and efficient gene editing.
The mbDNA Advantage
- High-purity, synthetic ssDNA templates
- Enhanced efficiency and minimal toxicity
- Capacity for multi-kilobase sequences
- Compatibility with various CRISPR nucleases
- Scalable production
As a pioneer in enzymatic DNA synthesis, Touchlight is leveraging its expertise to meet the growing demand for effective, non-viral gene therapies. Our mbDNA technology is attracting significant interest from leading pharmaceutical and biotechnology firms, demonstrating its potential to revolutionise gene editing applications.
Access the article to learn more about how mbDNA is setting new standards for diverse gene therapy applications and making treatments safer and more accessible.
Authors – Elena Stoyanova, Ph.D. & Tom Adie, Ph.D.
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About doggybone DNA (dbDNA™)
Doggybone or dbDNA™ is linear, double stranded, covalently closed DNA vector which is produced in an enzymatic manufacturing process. It can incorporate a gene of interest from 600bp to >20kb making it very flexible to support a range of genetic medicines.