This white paper explores how Touchlight is redefining DNA payload design for next-generation gene editing and non-viral gene therapy. It introduces innovative circular DNA architectures such as mbDNA, sscDNA, hsscDNA, and dscDNA—that enable precise, scalable, and efficient gene insertion across diverse modalities like HDR, HITI, recombination, and transposition. Download this whitepaper to learn how these payloads overcome limitations of traditional templates, reduce cytotoxicity, and unlock new therapeutic possibilities.

In this white paper, you’ll learn:

• Why payload architecture matters: How the structure and composition of DNA templates influence integration efficiency, safety, and therapeutic outcomes.
• Touchlight’s innovations: The unique benefits of custom circular DNA formats (single-stranded, hybrid, and double-stranded) for gene editing and non-viral delivery.
• Future applications: How these technologies enable large gene insertions, improve tolerability by reducing immune activation, and accelerate the development of advanced cell and gene therapies.