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APPLICATIONS

dbDNA™ platform solutions for the
next generation of genetic medicines

At Touchlight, we’re pioneering cell-free DNA technology that’s reshaping what’s possible in genetic applications. By empowering innovators with high-purity DNA, we’re accelerating the development of next-generation therapies that have the potential to transform lives.

How it works

Our dbDNA™ eliminates biological limitations, ensuring high-purity, scalable DNA synthesis. Using enzymatic processes, we deliver optimised DNA vectors to help you bring cutting-edge genetic applications to fruition.

1

The starting DNA template containing the sequence of interest and bacterial backbone is denatured.

2

Φ29 DNA Polymerase and primers initiates amplification, producing long, linear, double stranded concatemers.

3

Protelomerase binds the linear DNA at specified sites and performs a cleavage-joining reaction to produce dbDNA™.

4

The mixture is partially purified to remove low molecular weight impurities and enzymes.

5

Targeted restriction enzymes are added to selectively cut and digest the bacterial backbone DNA sequences.

6

Exonucleases, to which dbDNA™ is resistant, remove the open fragments of backbone DNA sequences, producing dNMPs.

7

The mixture is purified to remove the dNMPs and processing enzymes.

8

The dbDNA™ is finally formulated, filtered, dispensed under laminar air flow, and quality checked prior to release.

OUR APPLICATIONS

The standard in DNA technology for modern medicine

Our advanced cell-free DNA technology platform supports a wide range of genetic medicine applications, from mRNA, viral vectors, non-viral, gene editing to vaccines. Designed for purity, speed and scalability, we are here to help you focus on your therapeutic development.

mRNA

Efficient mRNA synthesis with high-purity, scalable dbDNA™

EXPLORE

AAV

Simplify AAV vector development with cell-free dbDNA™
EXPLORE

Gene Editing

Streamline gene editing with high-purity, customisable dbDNA™
EXPLORE

Lentivirus

Improve lentiviral production efficiency with fermentation-free dbDNA™
EXPLORE

DNA Vaccines

Speed up DNA vaccine development with GMP-ready dbDNA™
EXPLORE

Non-Viral Gene Therapy

Advance non-viral gene therapy with enzymatic dbDNA™ technology
EXPLORE

Do you need support or have questions?

Find out how our cell-free DNA technology could accelerate your genetic medicine projects.

  • Industry-leading expertise in enzymatic DNA production.
  • Custom solutions tailored to your specific research needs.
  • Scalable, high-purity DNA to support innovative therapies.
  • Let’s drive innovation in genetic medicine with enzymatic DNA technology together.
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Touchlight pioneers scalable, cell-free DNA technology, transforming gene therapy and genetic medicine. With a commitment to innovation, excellence, and a diverse team, we push boundaries to deliver safer, more efficient solutions for the future.

Applications

Gene editing

mRNA

AAV

Lentivirus

DNA Vaccines

Non-viral gene therapy

Custom Manufacturing

Discovery Scale

R&D Scale

SMart GMP Scale

GMP Scale

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