mbDNA™ (megabulb DNA) represents a breakthrough in non-viral gene-editing technology. Its unique circular single-stranded DNA architecture, with a modifiable double stranded stem region and a fully customisable sequence free of phage or bacterial-derived elements, is specifically engineered to serve as an exceptionally efficient template for HDR. Following nuclear delivery, mbDNA consistently enables enhanced knock-in (KI) efficiency in both immune and stem cells whilst maintaining high viability. Compatible with electroporation and lipid nanoparticle (LNP) formulations, this versatile vector exemplifies the promise of next-generation non-viral systems optimised for safe, efficient, and flexible gene-editing applications.

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