How to Scale DNA Production Effectively to Meet the Needs of Genetic Medicines DNA is the blueprint of life, carrying the molecular instructions that tell every cell how to…
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This application note highlights the advantages of dbDNA™, a linear, enzymatically amplified DNA construct, as a cell-free alternative to plasmid DNA (pDNA) for lentiviral vector (LVV) production. Manufactured under GMP…
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In this session, Elena Stoyanova, PhD (Touchlight) introduces mbDNA™ (Megabulb DNA), a novel single-stranded circular DNA template featuring a customizable stem region and fully user-defined sequence. Chesney Michels, PhD (ElevateBio)…
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MegaBulb DNA: Enabling better non-viral gene therapy with mbDNA – a cell-free circular ssDNA
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Touchlight’s dbDNA™ enables fast, scalable GMP-grade AAV production with fewer impurities and no bacterial sequences, confirmed by nanopore sequencing.
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dbDNA™: The Future of AAV Production Recombinant adeno-associated virus (AAV) is one of the most promising delivery vehicles for genetic medicines, offering potential to treat a range of previously…
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From Lab to Clinic: How z- dbDNA™ is Changing RNA Cell Therapy RNA is revolutionising cell therapy. Whether it's encoding genome-editing tools such as Cas9 to make precise DNA…
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CRISPR HDR Breakthrough with mbDNA™: ssDNA Template Boosts Cell Viability & Scalability CRISPR has transformed our ability to edit genomes, enabling targeted insertions, deletions, and base corrections. Yet…
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mbDNA™ is a synthetic, circular single-stranded DNA (ssDNA) vector engineered to overcome the limitations of both viral and non-viral gene-editing templates. By combining a customisable double-stranded stem region with a…
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Touchlight’s circular DNA offerings introduces a suite of innovative architectures, mbDNA™, sscDNA, hsscDNA, and dscDNA, designed to overcome the limitations of traditional gene editing tools. These constructs offer enhanced stability,…
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