Resources Archives

Jul 07

Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines

By Alexandria Salam Resources

This article presents a comparative study between traditional plasmid DNA vaccines and novel enzymatically produced linear DNA constructs known as "Doggybones." These linear constructs, which exclude unnecessary bacterial elements, demonstrated…

Jul 07

Novel synthetic plasmid and DoggyboneTM DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice

By Alexandria Salam Resources

CAR T cell therapy has shown remarkable success in treating blood cancers, but current production methods using viral vectors are extremely expensive, limiting patient access. In this groundbreaking study, researchers…

Jul 07

Cell-Free DNA for AAV production

By Alexandria Salam Resources

Replacing plasmid DNA with enzymatically produced DNA in your AAV production eliminates many issues around complex or unstable sequences, purity, speed to manufacture, safety and scalability. Many biotech and pharma…

Jul 02

Leveraging Synthetic DNA in AAV Manufacturing to Increase Efficiency

By Alexandria Salam Resources

Discover how synthetic, backbone-free DNA offers a safer, scalable alternative to traditional plasmid DNA for AAV production, addressing key challenges in transfection efficiency, cost, and impurity control. Download the poster…

Jul 01

CAR T Cell Generation by piggyBac Transposition from Linear dbDNA Vectors Requires Transposon DNA-Flanking Regions

By Alexandria Salam Resources

Jun 30

Improved CRISPR Gene Editing with dbDNA as a Knock-In Template

By Caitlin Magee Resources

Touchlight’s robust and rapidly scalable manufacturing technology, offers a reliable and effective alternative to pDNA as a knock-in template for CRISPR and, thus, promises to advance non-viral gene therapy. Download…

Jun 30

Addressing pDNA challenges in large-scale manufacturing of rAAV and rLV

By Caitlin Magee Resources

As gene therapy accelerates, the demand for scalable viral vector manufacturing has never been greater. Yet traditional plasmid DNA (pDNA) remains a limiting factor, slowed by scalability challenges, bacterial contamination…

Jun 30

dbDNA as a rapid and scalable solution to industrial lentiviral vector manufacturing

By Caitlin Magee Resources

Here, we demonstrate that dbDNATM can be optimised for the manufacture of high titre LVV.

Jun 30

SARS-CoV-"-Doggybone-DNA-Vaccine-Article-Header-Image

SARS-CoV-2 Doggybone DNA vaccine produces cross-variant neutralising antibodies and is protective in a COVID-19 animal model

By Caitlin Magee Resources

The most effective way to end the COVID-19 pandemic is through the development of medical countermeasures to combat SARS-CoV-2 infection and disease. The rise of the variants has also illustrated…

Jun 30

Safe and Stable Generation of Human iPSCs Using dbDNA™ Vectors

By Caitlin Magee Resources

Induced pluripotent stem cells (iPSCs) represent a transformative platform for regenerative medicine and cell therapy, but clinical success depends on safe and reliable reprogramming methods. This study reports the first…

Resources

Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines

Novel synthetic plasmid and DoggyboneTM DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice

Cell-Free DNA for AAV production

Leveraging Synthetic DNA in AAV Manufacturing to Increase Efficiency

CAR T Cell Generation by piggyBac Transposition from Linear dbDNA Vectors Requires Transposon DNA-Flanking Regions

Improved CRISPR Gene Editing with dbDNA as a Knock-In Template

Addressing pDNA challenges in large-scale manufacturing of rAAV and rLV

dbDNA as a rapid and scalable solution to industrial lentiviral vector manufacturing

SARS-CoV-2 Doggybone DNA vaccine produces cross-variant neutralising antibodies and is protective in a COVID-19 animal model

Safe and Stable Generation of Human iPSCs Using dbDNA™ Vectors

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